Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain.

Transl Psychiatry · 2017 · PMC5545725 · PMID 28094812

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantP <0.0001actually significant

Dopamine transporter mRNA and protein levels There was a highly significant 45% decrease in DAT mRNA levels (F=17.73; df=55; P <0.0001) and also a significant 37% decrease in the levels of VMAT2 mRNA (F=6.54; df=54; P =0.014) in the substantia nigra of schizophrenia cases when compared with controls ( Figures 3a and b ).

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did not reach statistical significanceP =0.070so close (0.05 < p ≤ 0.1)

Aromatic acid decarboxylase mRNA levels We found a decrease in AADC mRNA (22.49%) in substantia nigra from schizophrenia relative to controls; however, this difference did not reach statistical significance (F=3.417; df=54; P =0.070; Figure 1e ).

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