MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls.

As a post hoc analysis, when only patients were considered (and not controls), the same general pattern of results were observed as for the full group, with the relationship between higher polygene scores and lower test accuracy remaining significant at the P =10 −5 threshold, and nominally significant at the P =0.05 threshold.

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Multiple declarative memory subtests (the logical memory [immediate/delayed] and faces subtests [immediate/delayed] of the WMS III) were highly significant at each score threshold, surviving a stringent Bonferroni correction for the five cognitive domains analyzed.

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The most markedly significant domain was for declarative memory functioning.

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