Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.

Sci Rep · 2017 · PMC5547153 · PMID 28785061

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failed to reach statistical significanceno p-value reported

In fact, there was a trend towards increased conjugation of SUMO-1 that failed to reach statistical significance compared to the DMSO control (Fig. 2 ).

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