Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia.

There was no association of SOCS1 expression with any other chromosome change. Regarding the molecular gene mutations ( Table 1 ), higher SOCS1 expression was closely associated with NPM1 mutation (33 vs 14.4%, P =0.002) and DNMT3A mutation (22.3 vs 10.8%, P =0.029), and showed a trend to be associated with FLT3 /ITD (30.4 vs 19.8%, P =0.089), but was inversely correlated with CEBPA double mutation (1.8 vs 14.4%, P =0.001).

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