Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system.

21 , 22 , 23 , 24 As we investigated the liraglutide effects in a healthy lean animal model without leptin resistance, an observed trend towards reduced plasma leptin levels after chronic intrahypothalamic treatment could be responsible for the body weight regain, as this reduction has been suggested to increase caloric intake. 21 , 24 Thus, the body weight regain seems to be a natural protective counter-regulatory physiological res

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The subcutaneous adipose tissue volume showed a trend towards reduced adipose tissue volume gain by intrahypothalamic liraglutide treatment ( Figure 3b ) compared with intrahypothalamic vehicle group.

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