Immunohistochemistry confirmed these observations, showing increased levels of CHOP and phosphorylated eIF2 α (eIF2 α -P) in Tuj1 + RGCs ( Figures 3c–e ), although the increase of CHOP at 2WPI did not reach statistical significance.
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Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss.
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