Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.

A 28% increase in CatB activity was found after only the first day of lactacystin treatment (nearing significance with p = 0.054), and subsequent treatment days resulted in markedly up-regulated activity, increasing by 62–109% in a time-dependent manner (p<0.001).

also in 225 other papers

A difference was apparent in that lactacystin elicited earlier CatB up-regulation compared to Aβ 42 ’s effect that was delayed more than 4 days.

also in 830 other papers

With regards to proteasomal function, rather than a decrease for an inverse effect with respect to the CatB modulation, PADK elicited a 15% increase in proteasome activity, albeit not quite statistically significant ( Fig 7b , right bars).

also in 341 other papers