The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress.

Immunoblot analysis showed that both Y-27632 and U73122 abolished O-1602-mediated decrease in GluA1 and GluN2A expression in the MO cortex, while the expression of GluN2B increased slightly but did not reach statistical significance (Fig. 5c ).

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