Cognitive clustering in schizophrenia patients, their first-degree relatives and healthy subjects is associated with anterior cingulate cortex volume.

Of these nominally significant regions at the whole-brain level ( P uncorrected < 0.001), the effects of the diagnosis on the insula, anterior cingulate cortex (ACC; Fig. 4 A, x , y , z = 1.5, 40.5, 19.5, T = 5.19), thalamus and frontal areas and the effects of cognition on the ACC ( Fig. 4 B, T = 4.35), insula, hippocampus, amygdala, superior temporal gyrus and frontal areas were still significant after applying the FWE correction ( FWE - corrected P < 0.05, Supplementary Tables 1 and 2).

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