Oxytocin Rapidly Changes Astrocytic GFAP Plasticity by Differentially Modulating the Expressions of pERK 1/2 and Protein Kinase A.

Further examination of the molecular association of cPKA and pERK 1/2 with GFAP in Co-IP experiments (Figure 7B ) revealed that molecular association of GFAP with pERK 1/2 (204.0 ± 23.6% of control, n = 3, P < 0.05) increased significantly ( n = 3, P < 0.05) at the initial stage of suckling; the Co-IP of cPKA with GFAP was increased in all the three cases although the increase in the average level (178.2 ± 30.8% of control, P = 0.053) did not reach statistical significance due to the relatively low power.

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