Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis.

Consequently, without changing the timing of cellular beating, the Nkx2.5-positive cardiac progenitor cell population was significantly increased about 4-fold in the Cited4-hcgp7 group compared with the control group ( Fig 3D ); meanwhile, the Nkx2.5-positive cardiac progenitor cell population was decreased in the siCited4-hcgp7 group compared with the control group, although this did not reach statistical significance ( Fig 3D ).

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