Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal.

Interestingly, administration of LOX-specific control antibody M64 also seem to have an impact on average collagen content ( figure 7 E), although this did not reach statistical significance when compared with the placebo group.

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Quantitative morphometry confirmed a highly significant 3.5-fold reduction in Ki-67(+) ductal cells, paralleled by a 1.9-fold increase in Ki-67(+) hepatocytes ( figure 4 C).

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