Effects of metal ions on the structure and activity of a human anti-cyclin D1 single-chain variable fragment AD5.

Although low concentrations of Cu 2+ reduced the binding activity of AD5 to cyclin D1 and relatively high concentrations of Cu 2+ enhanced the binding activity of AD5 to cyclin D1, the results did not reach statistical significance when compared with 0.00 M Cu 2+ treatment ( Fig. 5 ).

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