Barely Significant
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The CREST-E study of creatine for Huntington disease: A randomized controlled trial.

Neurology · 2017 · PMC5562960 · PMID 28701493

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nominally significantno p-value reported
Among 41 measures analyzed, none showed even nominally significant differences between treatment groups.

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a positive trendno p-value reported
However, a prespecified subgroup analysis of sex revealed a positive trend in male participants and a negative effect in female participants.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.