Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE.

Bonomo Despite similar bacterial densities, diabetic but not nondiabetic mice experienced hypothermia, severe metabolic acidemia (low blood pH, low serum bicarbonate, and high base deficit), and markedly higher serum levels of interleukin-1β (IL-1β), IL-10, and tumor necrosis factor (TNF) than nondiabetic mice ( P < 0.05 for all comparisons), plus a strong trend toward higher levels of IL-6 ( P = 0.05) ( Fig. 2A and B ).

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