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Economic analysis and budget impact of clostridial collagenase ointment compared with medicinal honey for treatment of pressure ulcers in the US.

Clinicoecon Outcomes Res · 2017 · PMC5566395 · PMID 28860830

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One trial 26 showed a quantitative difference favoring debridement with CCO compared to another proteolytic enzyme, fibrinolysin/deoxyribonuclease, but the results did not reach statistical significance.

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