IL-4 stimulation induced no observable changes in surface CLIP expression ( Fig 8B ), and no significant changes for HLA-DM, except in the classical subset, which showed a trend for increased HLA-DM, with 4/6 samples increasing HLA-DM (average increase 1.6x, Fig 8C ), and decreased CLIP:HLA-DR ratio after IL-4 ( Fig 8D ).
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The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines.
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