T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas.

10 , 11 We suspected that DD tumors would have higher levels of inflammatory genes compared with WD tumors because they often acquire additional genetic mutations, 30 and we observed a nonsignificant trend in support of this (see Supporting Information Fig. 8).

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Genes in zones 1 and 4 had higher calculated variance in UPS and LMS specimens; this included CD274 (PD‐L1), in which a strong trend toward higher expression in UPS and LMS specimens was noted, suggesting that further analysis would be warranted.

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