A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.

PLoS Genet · 2017 · PMC5570506 · PMID 28806762

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Notably, homozygous expression of the Becn1 F121A mutation decreased mortality in PDAPP mice, while the autophagy-deficient PDAPP Bcl2 AAA mice showed a trend of exacerbated mortality compared to the PDAPP mice with normal autophagy ( Fig 4 ).

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