Neonatal mouse hippocampus: phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of rapamycin signaling.

The multi-center Premature Infants in Need of Transfusion (PINT) trial showed a trend toward better short-term neurodevelopment in preterm infants randomized to receive treatment at a higher target hematocrit concentration ( 2 ), while the single-center Iowa trial showed better long-term outcomes in the infants previously randomized to a lower target ( 3 ).

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