Dyslipidemic Diet-Induced Monocyte "Priming" and Dysfunction in Non-Human Primates Is Triggered by Elevated Plasma Cholesterol and Accompanied by Altered Histone Acetylation.

Importantly, the onset of monocyte priming coincided with an increase in total plasma cholesterol levels (compare Figures 2 C and 1 A), and there was a highly significant correlation ( P < 0.001) between plasma cholesterol levels and monocyte chemotaxis (Figure 2 D).

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The DD-fed group also displayed a 30.1% increase ( P = 0.044) in platelet counts in response to 8 weeks of DD feeding (Figure 3 D); however, the difference in platelet concentrations between DD-fed baboons and MD-fed baboons also did not reach statistical significance ( P = 0.163; Figure 3 D).

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In addition, the correlation between monocyte chemotaxis and Ac-H3 K18 status in these cells ( P = 0.092) as well as Ac-H3 K23 ( P = 0.051) nearly reached significance (Figures 7 B,C).

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