Population Pharmacokinetics of Brentuximab Vedotin in Patients With CD30-Expressing Hematologic Malignancies.

Study 5 25 showed a trend of decreased ADC exposure and increased MMAE exposure in patients with hepatic impairment (defined as Child‐Pugh classes A to C) and patients with severe renal impairment (CRCL < 30 mL/min); however, that study contributed just 4 patients with renal impairment and none with hepatic impairment to the PopPK data set.

also in 53,322 other papers