Apolipoprotein L1 risk variants associate with prevalent atherosclerotic disease in African American systemic lupus erythematosus patients.

These associations remained marginally significant when adjusting for important CVD risk factors including ESRD, smoking, average prednisone dose, BMI>25, and hypertension; however, the association did not meet a more stringent significance level after adjusting for multiple comparisons (OR 3.5; 95% CI 1.0–11.9; p = 0.046).

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Though the differences did not achieve statistical significance, the 2-risk-allele group showed a trend towards lower eGFR, compared to patients with zero or one risk alleles.

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