Tumor-Stroma Crosstalk in Bone Tissue: The Osteoclastogenic Potential of a Breast Cancer Cell Line in a Co-Culture System and the Role of EGFR Inhibition.

Int J Mol Sci · 2017 · PMC5578045 · PMID 28758931

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As shown in Figure 2 , we found that the COCO with MSC showed a trend towards the upregulation of two genes involved in the bone vicious cycle: EGFR and RANK [ 36 , 40 , 41 ], the latter showing an increase by over 1.5 times the basal level. 2.2.

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