Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.

Physiol Rep · 2017 · PMC5582266 · PMID 28821596

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failed to reach significanceno p-value reported

In RNCMs incubated in control media and exposed to hypoxia, the decrease in ATP levels failed to reach significance when compared with control conditions.

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did not reach statistical significanceno p-value reported

The results indicate supplementation with Cr, AICAR, or both increased the mean value of ATP content; however, this increase did not reach statistical significance in cultures grown under control oxygen conditions (Fig. 5 A).

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