Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation.

J Exp Med · 2017 · PMC5584112 · PMID 28778989

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highly significantno p-value reported

1, B and C ), a greater than fivefold and highly significant overrepresentation (Table S2), suggesting altered lysosome or lysosome-related function in the brains of GRN −/− mice ( Lui et al., 2016 ).

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did not reach statistical significanceno p-value reported

Basal LC3 II levels were slightly higher in GRN −/− BMDMs relative to GRN +/+ BMDMs, although this did not reach statistical significance ( Fig. 3, D and E ).

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