Sequential vs concurrent epirubicin and docetaxel as adjuvant chemotherapy for high-risk, node-negative, early breast cancer: an interim analysis of a randomised phase III study from the Hellenic Oncology Research Group.

From the exploratory variables included in the univariate analysis, only hormone receptors had a significant influence on DFS (HR: 1.683, 95% CI: 1.056–2.683, P =0.029), whereas the type of treatment had a marked trend but not statistically significant (HR: 1.591, 95% CI: 0.990–2.556, P =0.055).

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In addition, the relatively small sample size, the borderline significance of the primary outcome, the omission of cyclophosphamide on the anthracycline arm, as well as the non uniform assessment of HER2 status and the initial inclusion of a small number of HER2 positive patients are some other potential weaknesses of our study.

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