Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior.

Nevertheless, for the reviewer’s benefit, even when we compare the PV-hM4D mice to all 59 historical data points, we see a nearly significant difference whereas control PV-eYFP mice are more similar to unmodified RI-trained mice: But as it stands now, I am not fully convinced that the hm4D manipulation produces less habitual behavior.

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