Switch From Fetal to Adult <i>SCN5A</i> Isoform in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease-Causing Mutation.

At potentials of −55 to −35 mV, I Na density was slightly reduced compared with Ctrl1 and Ctrl2 ( P <0.05), and maximal peak current density was reduced by ≈30%, although this difference did not reach statistical significance (Figure 2 B).

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