Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ⁽⁺⁾CD8αα⁽⁺⁾ intraepithelial lymphocytes.

Consistent with this, FVB/n mice possessed a lower proportion (approaching significance) of CD71 (+) i.c.TCRβ (+) proliferating DN3 cells 18 (Fig. 2C ), that expressed significantly lower levels of CD5 (Fig. 2D ), a recognised marker of TCR signal strength 19 , than similar cells from C57BL/6 mice, suggesting that inefficient β-selection may be due to weak preTCR signalling in FVB/n animals.

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