Does supplementation with carnosine improve cardiometabolic health and cognitive function in patients with pre-diabetes and type 2 diabetes? study protocol for a randomised, double-blind, placebo-controlled trial.

22 An intervention study conducted in patients on a standard heart failure therapy who were suffering from stable chronic heart failure and severe left ventricular dysfunction demonstrated that chronic supplementation of carnosine showed a trend to increased end-diastolic volume. 32 More recently, supplementation with chicken extract, which is rich in carnosine and anserine, was shown to reduce heart rate variability in young females. 66 Nevertheless, human clinical trials with larger sample sizes investigating the role of carnosine on the prevention of cardiovascular diseases are lacking.

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