Reduced Slc1a1 expression is associated with neuroinflammation and impaired sensorimotor gating and cognitive performance in mice: Implications for schizophrenia.

Hippocampus Although there was a highly significant effect of Section Level on multiple hippocampal morphometry measures, there were no significant main effects of Genotype or Sex.

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However, we observed two nominally significant interaction effects.

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Moreover, these same effects appear to be present in KO Slc1a1 -/- mice and are an equivalent magnitude; 2) Slc1a1 +/- mice display reduced thickness of DMPFC, particularly layer V, which is also consistent with neuroanatomical findings in schizophrenia; 3) Slc1a1 +/- mice exhibit a lower ratio of reduced to oxidized glutathione (GSH/GSSG) as well as a possible trend for increased oxidative DNA damage in the brain; 4) There appears to be compensatory or downstream effects in the brains of Slc1a1 +/- mice, that lead to significant changes in the expression of genes and pathways involved in synaptic and cognitive functions; 5) There are robust changes in the expr

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Our results with the Elevated Plus Maze (EPM) showed a non-significant increase in time spent in the closed versus open arms of the maze, but this difference did not achieve significance ( Fig 1 ; Table 1 ) .

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