Inhibition of Y1 receptor signaling improves islet transplant outcome.

Nat Commun · 2017 · PMC5591241 · PMID 28887564

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0.0600

closest p · 1.2× alpha

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The sentences

a strong trendP = 0.06so close (0.05 < p ≤ 0.1)

Interestingly, NOD mice treated with BIBO3304 displayed a significant decrease in glucose levels (Placebo, 5.35 ± 0.11 mM; BIBO3304, 5.03 ± 0.09 mM; * P < 0.05), which is associated with a strong trend to increased insulin levels (Placebo, 73.31 ± 9.42 pM; BIBO3304, 103.2 ± 11.87 pM; P = 0.06), indicating that β-cells in a T1D environment are responsive to the inhibition of Y1 receptor signaling.

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a slight trendno p-value reported

1f ), whereas mice receiving a minimal number of WT islets had only a slight trend to improved blood glucose control by day 15 post-transplantation, which never completely normalized (Fig. 1f, g ).

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