By clinical endpoint, significant reduction in circulating apelin concentration was found in ACS (WMD: -1.690 ng/mL, P = 0.005) or CAD (WMD: -1.099 ng/mL, P = 0.011) patients when compared with controls, and only marginally significant reduction was found in AMI patients.
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Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies.
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