Principal contribution of HLA-DQ alleles, DQB1*06:04 and DQB1*03:01, to disease resistance against primary biliary cholangitis in a Japanese population.

In the present study, we examined the effects of HLA polymorphisms on the development of PBC and demonstrated that multiple HLA alleles show highly significant genome wide-association signals for single-nucleotide polymorphisms (SNPs) in the HLA region.

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Three hundred and five nominally significant association signals were distributed from the HLA-A to HLA-DP loci in accordance with the results of the HLA association analysis (Fig. 1A ).

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