Regulation of Human Macrophage M1-M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1.

In M2-polarized Mf, hypoxia was effective at inhibiting TNFα (from 45 ± 45 to 27 ± 19 pg/mL), CCL18 (from 1,851 ± 174 to 1,515 ± 179 pg/mL), and CCL24 (from 718 ± 138 to 443 ± 119 pg/mL) release (by a mean of about 50, 20, and 40%, respectively), even if differences did not reach statistical significance given the high variability among different samples, while it did not affect secretion of IL-12 (from 2.4 ± 2.4 to 3.2 ± 3.2 pg/mL), IL-1β (0.0 ± 0.0 pg/mL), and TGFβ (from 493 ± 97 to 456 ± 92 pg/mL).

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