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Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90.

Sci Rep · 2017 · PMC5596021 · PMID 28900199

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The high tumorigenic capacity of sorted EpCAM + cells compared with unsorted cells was confirmed in vivo , although the difference did not reach statistical significance (Supplementary Fig. 2B and C ).

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