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A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective.

Circulation · 2017 · PMC5598907 · PMID 28674110

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The inverse association between DKK3 and CCA-IMT was more pronounced in subjects with high (≥44.1 pmol/L; ie, ≥median) DKK1 level (age- and sex-adjusted regression coefficient [95% confidence interval] for a 1-SD unit higher DKK3 level, -0.018 [-0.037 to 0.001]) than in those with low (<44.1 pmol/L) DKK1 level (age- and sex-adjusted regression coefficient [95% confidence interval] for a 1-SD unit higher DKK3 level, -0.011 [-0.027 to 0.004]), but this interactive effect between DKK1 and DKK3 did not reach statistical significance ( P interaction =0.17).

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