Population Pharmacokinetics and Exposure Response Assessment of CC-292, a Potent BTK Inhibitor, in Patients With Chronic Lymphocytic Leukemia.

Although body weight and albumin levels appeared to be positively correlated with CL/F in the graphic analyses (correlation coefficient = 0.192), these correlations did not reach statistical significance in the following covariate model assessment.

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Because QD and BID dose regimens showed different response rates in exploratory analysis, and dosing schedule (QD and BID) was identified as a marginally statistically significant predictor of clinical response due to the limited number of patients enrolled in each dose regimen, logistic regressions were conducted separately for each dose regimen.

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