Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status.

In total, 15 lifestyle factors were observed to interact with GS BMI , of which alcohol intake frequency, usual walking pace, and Townsend deprivation index, a measure of socioeconomic status, were all highly significant ( p = 1.45*10 −29 , p = 3.83*10 −26 , p = 4.66*10 −11 , respectively).

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The final model generated by SRL included gene-environment interaction terms for ten lifestyle factors ( S10 Table , supplementary Data), of which eight were nominally significant: alcohol intake frequency ( p = 2.82*10 −15 ), usual walking pace ( p = 1.55*10 −14 ), frequency of 10+ minute walks ( p = 6.26*10 −4 ), smoking status (p = 1.45*10 −3 ), frequency of vigorous exercise ( p = 2.28*10 −3 ), number of vehicles in household (p = 1.03*10 −2 ), TDI (p = 3.02*10 −2 ) and frequency of tiredness/lethargy (p = 3.87*10 −2 ) and.

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