The genomic landscape of human cellular circadian variation points to a novel role for the signalosome.

In order to eliminate effect of these confounding parameters we residualized our phenotypes using backward multiple regression model (lme function in nlme R package): starting from all variables included into the model we step by step eliminated less significant ones until all variables were nominally significant (p<0.05).

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At the genetic level, mostly not – i.e., as already mentioned in the context of Figure 1 , we do not find highly significant polymorphisms affecting both parameters.

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