A lower percentage of Bcl-xL KO P-KrasG12D mice developed PDAC at 12 months than littermate P-KrasG12D mice (35.7% [5 of 14] vs 83.3% [5 of 6]), although the difference did not reach statistical significance ( P = .07).
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Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and Apoptosis.
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