Whereas finerenone treatment at concentrations of 1 nM showed a clear trend towards reduced SMC proliferation rates, 10 nM finerenone sufficiently and significantly prevented aldosterone-induced SMC proliferation (* P <0.05 to serum-free, # P <0.05 to DMSO, n = 6, Fig 1A and 1B ).
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The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury.
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