Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.

In fact, a slight increase in DNase1L2 expression, even though it did not reach statistical significance (P = 0.128), may occur in Trex2-deficient skin (Fig. 4 ) that could partially compensate Trex2 loss.

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