Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.

In the most significant HLA-DRA-DQA1 region, conditioning on HLA-DRB1 Leu67 ( P = 1.14 × 10 −29 , OR = 1.3) and HLA-DQA1 His129 ( P = 1.56 × 10 −13 , OR = 1.19) removed the effect of DQA1*01:02 ( P = 7.04 × 10 −22 , OR = 0.75, conditional P value is 0.54), DQA1*03:01 ( P = 3.99 × 10 −10 , OR = 1.27, conditional P value is 0.36), and rs3135359 ( P = 8.82 × 10 −21 , OR = 1.21, conditional P value is 0.06); however, the effect of rs2894257 ( P = 8.16 × 10 −36 , OR = 1.36, conditional P value is 1.2 × 10 −7 ) remained moderately significant.

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