Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy.

The study included MDD patients ( n = 744) and healthy controls ( n = 793), and found a highly significant decreased levels of TRP in depressed patients vs controls ( p < 0.001).

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(2014) demonstrated that monotherapy treatment with celecoxib had borderline significance in the relief of depressive symptoms ( Köhler et al., 2014 ).

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Both groups using NSAIDs (ibuprofen/naproxen or celecoxib) showed a trend towards a reduction in depressive symptoms in patients with osteoarthritis, based on the PHQ-9 scores ( Iyengar et al., 2013 ).

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