Estrogenic vascular effects are diminished by chronological aging.

Sci Rep · 2017 · PMC5610317 · PMID 28939871

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a negative trendno p-value reported

In addition, there was a negative trend between vasodilatory responses of human uterine arteries to estrogenic compounds and aging (Fig. 6D and F ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.