Barely Significant
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Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from <i>SNCA</i> rs356168.

Front Genet · 2017 · PMC5611418 · PMID 28979294

Europe PMCDOI
4
hedged sentences
0.0200
closest p · 0.4× alpha
0.0700
boldest claim

The sentences

borderline significantp = 0.02actually significant
Carriers of the rs356168-G allele demonstrated a borderline significant decrease of SNCA -mRNA levels in temporal brain tissues ( p = 0.02) compared to individuals homozygous for the ‘A’ allele.

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borderline significancep = 0.06so close (0.05 < p ≤ 0.1)
However, these expression differences between the homozygous genotypes were statically significant only in the temporal cortex and after correction for multiple comparisons (two analyzed brain tissues) showed only borderline significance ( p = 0.06).

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a trend toward significanceP = 0.07so close (0.05 < p ≤ 0.1)
In the temporal cortex, we detected a suggested dose effect of rs356168 on SNCA mRNA levels that showed a trend toward significance ( P = 0.07) ( Figure 1A ).

also in 3,729 other papers

did not reach statistical significanceno p-value reported
Similar trend, but weak, was observed in the analysis of frontal cortex samples, however, this analysis did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.