In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels.

In contrast, those SMA mice that received either PF-06738066 or RG3039 had a simultaneous pass rate of about 78%- almost a 40% improvement in their ability to pass the combined assay, but this did not reach statistical significance (Fisher’s exact test, P -value = 0.0708).

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