Microenvironment regulates the expression of miR-21 and tumor suppressor genes PTEN, PIAS3 and PDCD4 through ZAP-70 in chronic lymphocytic leukemia.

The targets of miR-21 defined in the gene set where also downregulated when comparing Ramos GFP-ZAP-70 cells and Ramos GFP, both stimulated with anti-IgM, although the difference did not reach statistical significance (enrichment score: −0.23; nominal p-value: 0.44) (Fig. 3d ).

also in 111,027 other papers